The first factor is loud noise which genuinely can damage the cells of your inner ear. The working environment where you go regularly such as construction work or factories can damage the inside of your ear. Such occupational noises are one of the major factors of inner ear damage. The doctor even says some medications such as sildenafil, antibiotic gentamicin, certain chemotherapy drugs, etc can easily damage the inner ear. You can face temporary effects while taking high doses of aspirin and antimalarial drugs.